Laboratories Studying DNA Replication at Roswell
Park Cancer Institute (RPCI) and the State University of New York at Buffalo
(SUNYAB)
Because DNA replication is essential for cellular proliferation, and
because cancer is a consequence of uncontrolled proliferation, a relatively
large number of scientists at Roswell Park Cancer Institute (RPCI) study
DNA replication and its regulation. These RPCI scientists are joined by
several additional scientists at the State University of New York (SUNYAB)
who also study DNA replication. All of these laboratories participate in
the Buffalo DNA Replication Group, which organizes two mini-symposia per
year--one just for Buffalo DNA replication labs and the second for labs
throughout western New York and southern Ontario.
Here is a list of some of the Buffalo area laboratories studying DNA
replication (other Buffalo investigators studying
DNA replication are invited to join this list; simply send me a URL for
your lab's web home page and a list of specific topics that you're currently
studying).
- William Burhans (RPCI)
- The cis-acting determinants of mammalian DNA replication origins
- The mechanisms by which DNA alkylation leads to inhibition of both
the initiation and elongation phases of DNA replication
- The mammalian checkpoint pathways leading from DNA damage to inibition
of initiation of replication
- The S. cerevisiae checkpoint pathways leading from DNA damage
to inibition of initiation of replication
- Joel Huberman (RPCI)
- The mechanisms controlling the times when specific fission and budding
yeast replication origins fire during S phase
- The cis-acting determinants of fission yeast DNA replication
origins
- The proteins interacting with fission yesat DNA replication origins
- The fission yeast checkpoint pathways leading from DNA damage
to inibition of replication
- David Kowalski (RPCI)
- The cis-acting determinants of DNA replication origins in budding
yeast
- Silencing of DNA replication origins in yeast chromosomes
- Anticancer drug effects on DNA replication in yeast chromosomes
- Functional identification and computer analysis of DNA unwinding elements
in replication origins
- Thomas
Melendy (SUNYAB)
- Mechanisms of initiation of human and viral DNA replication
- Cellular proteins involved in papillomavirus DNA replication
- S-Phase checkpoint mechanisms for regulating/inhibiting DNA replication
- John Yates (RPCI)
- The cis-acting determinants of Epstein-Barr virus DNA replication
origins
- The roles in DNA replication and plasmid maintenance of Epstein-Barr
nuclear antigen 1 (EBNA1)
- Genetic analysis of EBNA1
This page was updated on March 31, 2001
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