Most of you succeeded in answering this question at least partially correctly. I think that if you had thoroughly understood the figure from Wang et al. (1998) given near the end of my second lecture (the lecture on September 8), you would easily have been able to answer the question completely correctly.

There were two ways to answer the question, depending on your interpretation of the A, T, G and C on the left side of the diagram. Some of you interpreted the A, T, G and C to indicate that a sequence with the indicated nucleotide at the indicated position would hybridize to the indicated oligonucleotide. If you made that interpretation, then the correct answer would look like this:

If you interpreted the A, T, G and C to indicate that a sequence with the complementary nucleotide at the indicated position would hybridize at the indicated position, then the correct answer would look like this:

Note that in both cases hybridization by the homozygote to the tiled array that corresponds to the alternative allele is permitted only in the "mismatch" position in the central column that restores a correct match. All 4 oligonucleotides in the flanking columns contain at least one mismatch to the homozygote sequence and thus do not hybridize. If you have questions about this, please contact me for help.